Menopause. 2003;10(6):522-5.

“Femarelle treatment in postmenopausal women increases BMD without unwanted estrogenic effect.”

Tofupill/Femarelle (DT56a): a new phyto-selective estrogen receptor modulator- like substance for the treatment of postmenopausal bone loss.

After 12 months of treatment, BMD had increased in the study group by 3.6% in the lumbar spine (P = 0.039) and by 2.0% in the femoral neck (NS). In the low-dose group, BMD had decreased in the lumbar spine by 0.6% (NS) and by 0.6% in the femoral neck (NS). Comparison of the change in bone density between the groups yielded a significant difference for the lumbar spine (P = 0.037). Neither group showed a change in endometrial thickness and sex hormone levels nor reported any side effects of treatment.

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